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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cancersp</journal-id><journal-title-group><journal-title xml:lang="ru">Южно-Российский онкологический журнал/ South Russian Journal of Cancer</journal-title><trans-title-group xml:lang="en"><trans-title>South Russian Journal of Cancer</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2686-9039</issn><publisher><publisher-name>АНО "Перспективы онкологии"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37748/2686-9039-2021-2-1-6</article-id><article-id custom-type="elpub" pub-id-type="custom">cancersp-107</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзор</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Профилактика развития рака молочной железы</article-title><trans-title-group xml:lang="en"><trans-title>Preventive measures against development of breast cancer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1656-6565</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Выхристюк</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vykhristyuk</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Выхристюк Юлия Владимировна – к.м.н., доцент кафедры акушерства и гинекологии педиатрического факультета, SPIN: 2895-2327, AuthorID: 964177.</p><p>117997, Российская Федерация, г. Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Yulia V. Vykhristyuk – Cand. Sci. (Med.), associate professor of department of obstetrics and gynecology of pediatric faculty.</p><p>1 Ostrovityanova str., Moscow 117997, Russian Federation</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0514-9114</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ройтберг</surname><given-names>Г. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Roitberg</surname><given-names>G. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ройтберг Григорий Ефимович – д.м.н., профессор, академик РАН, заведующий кафедрой терапии, общей врачебной практики и ядерной медицины; президент клиники, SPIN: 1032-9122, Author ID: 218525.</p><p>117997, Российская Федерация, г. Москва, ул. Островитянова, д. 1</p><p>125047, Российская Федерация, г. Москва, 2-й Тверской-Ямской пер., д. 10</p></bio><bio xml:lang="en"><p>Grigory E. Roitberg* – Dr. Sci. (Med.), professor, academician of the RAS, head of the Department of therapy, general medical practice and nuclear medicine of faculty of additional professional education; president of the clinic, SPIN: 1032-9122, Author ID: 218525.</p><p>1 Ostrovityanova str., Moscow 117997, Russian Federation</p><p>10 2nd Tverskaya-Yamskaya lane, Moscow125047, Russian Federation</p></bio><email xlink:type="simple">jdorosh@medicina.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6078-9654</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дорош</surname><given-names>Ж. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dorosh</surname><given-names>J. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дорош Жанна Валентиновна – к.м.н., доцент кафедры терапии, общей врачебной практики и ядерной медицины, SPIN: 3592-4274, Author ID: 663889.</p><p>117997, Российская Федерация, г. Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Janna V. Dorosh – Cand. Sci. (Med.), department of therapy and family medicine, SPIN: 3592-4274, AuthorID: 663889.</p><p>1 Ostrovityanova str., Moscow 117997, Russian Federation</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6891-0332</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карасева</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Karaseva</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карасева Наталья Владимировна – старший преподаватель кафедры биологии и общей генетики Медицинского института, SPIN: 4709-6246, AuthorID: 224682.</p><p>117198, Российская Федерация, г. Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Natalya V. Karaseva – senior lectures, department of biology and general genetics of the Medical Institute, SPIN: 4709-6246, AuthorID: 224682.</p><p>6 Miklukho-Maklaya str., Moscow 117198, Russian Federation</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5817-9627</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Акобова</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Akobova</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Акобова Ребека Араевна – студентка 4 курса лечебного факультета Медицинского института.</p><p>117198, Российская Федерация, г. Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Rebeka A. Akobova – 4th year student of the general medicine faculty of the Medical Institute.</p><p>6 Miklukho-Maklaya str., Moscow 117198, Russian Federation</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.I.Pirogov Russian National Research Medical University (RNRMU)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Министерства здравоохранения Российской Федерации; ОАО «Медицина»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.I.Pirogov Russian National Research Medical University (RNRMU); Medicinа</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский университет дружбы народов»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples Friendship University of Russia (RUDN University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>25</day><month>03</month><year>2021</year></pub-date><volume>2</volume><issue>1</issue><fpage>50</fpage><lpage>56</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Выхристюк Ю.В., Ройтберг Г.Е., Дорош Ж.В., Карасева Н.В., Акобова Р.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Выхристюк Ю.В., Ройтберг Г.Е., Дорош Ж.В., Карасева Н.В., Акобова Р.А.</copyright-holder><copyright-holder xml:lang="en">Vykhristyuk Y.V., Roitberg G.E., Dorosh J.V., Karaseva N.V., Akobova R.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.cancersp.com/jour/article/view/107">https://www.cancersp.com/jour/article/view/107</self-uri><abstract><p>По данным российской статистики рак молочной железы занимает первое место среди злокачественных новообразований среди женщин (20,9%). Наибольшая доля случаев рака молочной железы выявляется у женщин в возрасте от 35 до 55 лет. Поэтому актуальным вопросом становится не только оказание специализированной медицинской помощи пациентам, но и профилактика развития этого заболевания. Почти 70% злокачественных новообразований, в том числе и рак молочной железы, провоцируются экзогенными факторами. В этой статье представлен обзор литературы о первичной профилактике рака молочной железы. Установлено, что образ жизни женщины, питание, ее физическая активность, вредные привычки могут оказывать потенцирующее влияние на развитие рака молочной железы. Заключение. В настоящее время профилактика рака молочной железы играет ключевую роль в борьбе с этим заболеванием. Женщины среднего возраста (на который приходится основной пик заболеваемости) должны понимать, что путем изменения поведения возможно снизить риск развития этого заболевания. Кроме того, повышение осведомленности женщин о раке молочной железы и его профилактике может способствовать снижению заболеваемости и финансовых затрат на лечение.</p></abstract><trans-abstract xml:lang="en"><p>According to Russian statistics, breast cancer ranks fi rst among malignant neoplasms among women (20.9%). The largest proportion of breast cancer cases is detected in women aged 35 to 55 years. Therefore, an urgent issue is not only the provision of specialized medical care to patients, but also the prevention of the development of the disease. Almost 70% of malignant neoplasms, including breast cancer, are provoked by exogenous factors. This article provides an overview of the literature on primary breast cancer prevention. It is established that a woman's lifestyle, diet, physical activity, and bad habits can have a potentiating effect on the development of breast cancer. Conclusions. Currently, breast cancer prevention plays a key role in the fi ght against this disease. middle-aged women (who account for the main peak of morbidity) should understand that by changing behavior, it is possible to reduce the risk of developing breast cancer. In addition, increasing women's awareness of breast cancer and its prevention can help reduce the incidence and fi nancial costs of treatment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>профилактика</kwd><kwd>заболеваемость</kwd><kwd>индекс массы тела</kwd><kwd>употребление алкоголя</kwd><kwd>питание</kwd></kwd-group><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>prevention</kwd><kwd>morbidity</kwd><kwd>body mass index</kwd><kwd>alcohol consumption</kwd><kwd>nutrition</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Inchina V.I., Izbastyyeva M.D., Tarasova T.V., Ulanova T.V., Avanesov A.M., Khaydar D.A. Antitumor efficacy of liposomal doxorubicin hydrochloride in combination with tamoxifen. Experimental study. 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