cancerspЮжно-Российский онкологический журнал/ South Russian Journal of CancerSouth Russian Journal of Cancer2686-9039АНО "Перспективы онкологии"10.37748/2686-9039-2021-2-3-4cancersp-112Research ArticleОбзорREVIEWБиомаркеры для иммунотерапии немелкоклеточного рака легкогоBiomarkers for non-small cell lung cancer immunotherapyhttps://orcid.org/0000-0003-0640-2994ХарагезовД. А.KharagezovD. A.

Харагезов Дмитрий Акимович – к.м.н., хирург, заведующий отделением торакальной хирургии

SPIN: 5120-0561

AuthorID: 733789 

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Dmitriy A. Kharagezov – Cand. Sci. (Med.), surgeon, head of department of thoracic surgery

SPIN: 5120-0561

AuthorID: 733789 

63 14 line str., Rostov-on-Don 344037

dmitr8@mail.ruhttps://orcid.org/0000-0002-6655-7632ЛазутинЮ. Н.LazutinYu. N.

Лазутин Юрий Николаевич – к.м.н., доцент, ведущий научный сотрудник отдела торакальной хирургии

SPIN: 5098-7887

AuthorID: 364457 

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Yuriy N. Lazutin – Cand. Sci. (Med.), associate professor, leading Researcher of the Department of Thoracic Surgery 

SPIN: 5098-7887

AuthorID: 364457 

63 14 line str., Rostov-on-Don 344037

lazutin.jurij@yandex.ruhttps://orcid.org/0000-0002-1410-122XЗлатникЕ. Ю.ZlatnikE. Yu.

Златник Елена Юрьевна – д.м.н., профессор, главный научный сотрудник лаборатории иммунофенотипирования опухолей

SPIN: 4137-7410

AuthorID: 327457

Scopus Author ID: 6603160432 

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Elena Yu. Zlatnik – Dr. Sci. (Med.), professor, chief Researcher of the Laboratory of Tumor Immunophenotyping 

SPIN: 4137-7410

AuthorID: 327457

Scopus Author ID: 6603160432 

63 14 line str., Rostov-on-Don 344037

ellada.mirzoyan@yandex.ruhttps://orcid.org/0000-0003-0874-5261СагакянцА. Б.SagakyantsA. B.

Сагакянц Александр Борисович – к.б.н., доцент, заведующий лабораторией иммунофенотипирования опухолей

SPIN: 7272-1408

AuthorID: 426904

ResearcherID: M-8378-2019

Scopus Author ID: 24329773900 

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Aleksandr B. Sagakyants – Cand. Sci. (Biol.), associate Professor, Head of the Laboratory of Tumor Immunophenotyping 

SPIN: 7272-1408

AuthorID: 426904

ResearcherID: M-8378-2019

Scopus Author ID: 24329773900 

63 14 line str., Rostov-on-Don 344037

asagak@rambler.ruhttps://orcid.org/0000-0002-0328-9714МирзоянЭ. А.MirzoyanE. A.

Мирзоян Эллада Арменовна – аспирант

SPIN: 2506-8605

AuthorID: 1002948 

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Ellada A. Mirzoyan – PhD student

SPIN: 2506-8605

AuthorID: 1002948 

63 14 line str., Rostov-on-Don 344037

ellada.mirzoyan@yandex.ruhttps://orcid.org/0000-0002-2589-7606МилакинА. Г.MilakinA. G.

Милакин Антон Григорьевич – онколог отделения торакальной хирургии

SPIN: 7737-4737

AuthorID: 794734 

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Anton G. Milakin – oncologist at the Department of Thoracic Surgery

SPIN: 7737-4737

AuthorID: 794734 

63 14 line str., Rostov-on-Don 344037

ellada.mirzoyan@yandex.ruhttps://orcid.org/0000-0003-4513-7548СтатешныйО. Н.StateshnyO. N.

Статешный Олег Николаевич – онколог отделения торакальной хирургии

SPIN: 9917-1975

AuthorID: 1067071 

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Stateshny N. Oleg – oncologist at the Department of Thoracic Surgery

SPIN: 9917-1975

AuthorID: 1067071 

63 14 line str., Rostov-on-Don 344037

ellada.mirzoyan@yandex.ruЧубарянА. В.ChubaryanA. V.

Чубарян Анна Васильевна – к.м.н., старший научный сотрудник, врач-онколог отделения торакальной хирургии

SPIN: 7307-0670

AuthorID: 842662 

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Anna V. Chubaryan – Cand. Sci. (Med.), senior Researcher, oncologist of the Department of Thoracic Surgery

SPIN: 7307-0670

AuthorID: 842662 

63 14 line str., Rostov-on-Don 344037

ellada.mirzoyan@yandex.ruhttps://orcid.org/0000-0002-6655-7632ЛейманИ. А.LeymanI. A.

Лейман Игорь Александрович – к.м.н., врач-онколог отделения торакальной хирургии

SPIN: 2551-0999

AuthorID: 735699 

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Igor A. Leiman – Cand. Sci. (Med.), oncologist at the Department of Thoracic Surgery

SPIN: 2551-0999

AuthorID: 735699 

63 14 line str., Rostov-on-Don 344037

toraxrnioi@yandex.ruФГБУ «НМИЦ онкологии» Минздрава РоссииРоссияNational Medical Research Centre for Oncology of the Ministry of Health of RussiaRussian Federation202106092021233141Copyright © Харагезов Д.А., Лазутин Ю.Н., Златник Е.Ю., Сагакянц А.Б., Мирзоян Э.А., Милакин А.Г., Статешный О.Н., Чубарян А.В., Лейман И.А., 20212021Харагезов Д.А., Лазутин Ю.Н., Златник Е.Ю., Сагакянц А.Б., Мирзоян Э.А., Милакин А.Г., Статешный О.Н., Чубарян А.В., Лейман И.А.Kharagezov D.A., Lazutin Y.N., Zlatnik E.Y., Sagakyants A.B., Mirzoyan E.A., Milakin A.G., Stateshny O.N., Chubaryan A.V., Leyman I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cancersp.com/jour/article/view/112

Открытие ингибирования иммунных контрольных точек произвело революцию в лечении многих солидных злокачественных новообразований, включая немелкоклеточный рак легкого (НМРЛ). Ингибиторы иммунных контрольных точек (ИИКТ) обладают способностью восстанавливать противоопухолевый иммунный ответ, блокируя торможение активации Т-лимфоцитов. Anti-programmed death-ligand 1, трансмембранный белок, лиганд к рецептору PD-1(PD-L1) в настоящее время является основным биомаркером эффективности анти-PD-1/ PD-L1 препаратов лечении НМРЛ без драйверных мутаций. Высокая мутационная нагрузка опухоли, предполагающая повышенную продукцию неоантигенов, также ассоциируется с эффективностью иммунотерапии. Микросателлитная нестабильность – другой биомаркер, одобренный для иммунотерапии при солидных опухолях, – редко наблюдается при НМРЛ. Первичная резистентность к ИИКТ характерна для онкодрайверного НМРЛ, приобретенная связана с иммуноредактированием в результате истощения потенциально иммуногенных неоантигенов. В обзоре обсуждаются последние достижения и будущие направления прогнозирования результатов иммунотерапии у больных НМРЛ.

The discovery of immune checkpoint inhibition has revolutionized the treatment of many solid malignancies, including non-small cell lung cancer (NSCLC). Immune checkpoint inhibitors (ICI) can restore the antitumor immune response by blocking the inhibition of T-cell activation. Anti-programmed death-ligand 1 (PD-L1) is currently the main biomarker of the effectiveness of anti-PD-1 / PD-L1 blockade in the treatment of NSCLC without driver mutations. High tumor mutational burden suggests an increased neoantigens load and has been associated with the effectiveness of ICI therapy. Microsatellite instability, a biomarker approved for immunotherapy across solid tumors, but it is uncommon in NSCLC. Primary resistance to ICIsis characteristic of NSCLC with driver mutations, acquired is associated with immunoediting resulting in the depletion of potentially immunogenic neoantigens. The review discusses recent advances and future directions for predicting the results of immunotherapy in patients with NSCLC.

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The authors declare that there are no conflicts of interest present.