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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cancersp</journal-id><journal-title-group><journal-title xml:lang="ru">Южно-Российский онкологический журнал/ South Russian Journal of Cancer</journal-title><trans-title-group xml:lang="en"><trans-title>South Russian Journal of Cancer</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2686-9039</issn><publisher><publisher-name>АНО "Перспективы онкологии"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37748/2686-9039-2023-4-3-1</article-id><article-id custom-type="edn" pub-id-type="custom">YSUVMK</article-id><article-id custom-type="elpub" pub-id-type="custom">cancersp-214</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Опыт хирургического лечения метастатических опухолей позвонков краниовертебральной локализации</article-title><trans-title-group xml:lang="en"><trans-title>Experience in surgical treatment of vertebral metastatic tumors of craniovertebral localization</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3061-6108</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кит</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kit</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p> </p><p>Кит Олег Иванович – академик РАН, д.м.н., профессор, генеральный директор, ФГБУ «НМИЦ онкологии» Минздрава России, г. Ростов-на-Дону, Российская Федерация.</p><p>ORCID: <ext-link xlink:href="https://orcid.org/0000-0003-3061-6108," ext-link-type="uri">https://orcid.org/0000-0003-3061-6108, </ext-link>SPIN: 1728-0329, AuthorID: <ext-link xlink:href="https://elibrary.ru/author_profile.asp?id=343182" ext-link-type="uri">343182</ext-link>, ResearcherID: <ext-link xlink:href="https://www.webofscience.com/wos/author/record/U-2241-2017" ext-link-type="uri">U-2241-2017</ext-link>, Scopus Author ID: <ext-link xlink:href="https://www.scopus.com/authid/detail.uri?authorId=55994103100" ext-link-type="uri">55994103100</ext-link></p></bio><bio xml:lang="en"><p> </p><p>Oleg I. Kit – Academician at the Russian Academy of Sciences, Dr. Sci. (Med.), professor, general director, National Medical Research Centre for Oncology, Rostov-on-Don, Russian Federation.</p><p>ORCID: <ext-link xlink:href="https://orcid.org/0000-0003-3061-6108," ext-link-type="uri">https://orcid.org/0000-0003-3061-6108, </ext-link>SPIN: 1728-0329, AuthorID: <ext-link xlink:href="https://elibrary.ru/author_profile.asp?id=343182" ext-link-type="uri">343182</ext-link>, ResearcherID: <ext-link xlink:href="https://www.webofscience.com/wos/author/record/U-2241-2017" ext-link-type="uri">U-2241-2017</ext-link>, Scopus Author ID: <ext-link xlink:href="https://www.scopus.com/authid/detail.uri?authorId=55994103100" ext-link-type="uri">55994103100</ext-link></p></bio><email xlink:type="simple">onko-sekretar@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0925-415X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Закондырин</surname><given-names>Д. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakondyrin</surname><given-names>D. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p> </p><p>Закондырин Дмитрий Евгеньевич – к.м.н., врач-нейрохирург, ФГБУ ВО «МГМСУ им. А. И. Евдокимова» Минздрава России, г. Москва, Российская Федерация.</p><p>ORCID: https://orcid.org/0000-0002-0925-415X </p></bio><bio xml:lang="en"><p> </p><p>Dmitry E. Zakondyrin – Cand. Sci. (Med.), MD, neurosurgeon, Moscow State Medical and Dental University named after A. I. Evdokimov, Moscow, Russian Federation.</p><p>ORCID: https://orcid.org/0000-0002-0925-415X</p></bio><email xlink:type="simple">russiandoctor@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2937-0470</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Росторгуев</surname><given-names>Э. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Rostorguev</surname><given-names>E. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p> </p><p>Росторгуев Эдуард Евгеньевич – д.м.н., заведующий отделением нейроонкологии, ФГБУ «НМИЦ онкологии» Минздрава России, г. Ростов-на-Дону, Российская Федерация.</p><p>ORCID: https://orcid.org/0000-0003-2937-0470, SPIN: 8487-9157, AuthorID: 794808, Scopus Author ID: 57196005138</p></bio><bio xml:lang="en"><p> </p><p>Eduard E. Rostorguev – Dr. Sci. (Med.), chief of neuro-oncological department, National Medical Research Centre for Oncology, Rostov-on-Don, Russian Federation.</p><p>ORCID: https://orcid.org/0000-0003-2937-0470, SPIN: 8487-9157, AuthorID: 794808, Scopus Author ID: 57196005138</p></bio><email xlink:type="simple">rostorguev@icloud.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Росторгуев</surname><given-names>В. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Rostorguev</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p> </p><p>Росторгуев Владимир Эдуардович – аспирант кафедры травматологии и ортопедии, лечебной физкультуры и спортивной медицины, врач травматолог-ортопед, ФГБОУ ВО «РостГМУ» Минздрава России, г. Ростов-на-Дону, Российская Федерация.</p></bio><bio xml:lang="en"><p> </p><p>Vladimir E. Rostorguev – PhD student, department of traumatology and orthopedics, physical therapy and sports medicine, MD, orthopedic traumatologist, Rostov State Medical University, Rostov-on-Don, Russian Federation.</p></bio><email xlink:type="simple">v.rostorguev@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маслов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Maslov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p> </p><p>Маслов Александр Андреевич – студент 4 курса, ФГБОУ ВО «РостГМУ» Минздрава России, г. Ростов-на-Дону, Российская Федерация.</p></bio><bio xml:lang="en"><p> </p><p>Aleksandr A. Maslov – 4 th year medical student, Rostov State Medical University, Rostov-on-Don, Russian Federation.</p></bio><email xlink:type="simple">Maslow@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «НМИЦ онкологии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Centre for Oncology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ ВО «МГМСУ им. А. И. Евдокимова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow State Medical and Dental University named after A. I. Evdokimov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «РостГМУ» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>07</day><month>08</month><year>2023</year></pub-date><volume>4</volume><issue>3</issue><fpage>6</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кит О.И., Закондырин Д.Е., Росторгуев Э.Е., Росторгуев В.Э., Маслов А.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Кит О.И., Закондырин Д.Е., Росторгуев Э.Е., Росторгуев В.Э., Маслов А.А.</copyright-holder><copyright-holder xml:lang="en">Kit O.I., Zakondyrin D.E., Rostorguev E.E., Rostorguev V.E., Maslov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.cancersp.com/jour/article/view/214">https://www.cancersp.com/jour/article/view/214</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Разработка методики хирургического лечения пациентов с метастатическим поражением краниовертебральной области.</p></sec><sec><title>Пациенты и методы</title><p>Пациенты и методы. В исследование включено 7 больных c метастатическим поражением краниовертебральной области, оперированных по поводу выраженной нестабильности, болевого синдрома, неврологического дефицита в период с 01.01.2014 по 30.09.2022 гг. Для оценки неврологического статуса и состояния пациентов использовали шкалы Frankel и Karnofsky в день поступления и выписки пациентов из стационара. Интенсивность болевого синдрома оценивали по визуально аналоговой шкале боли (ВАШ). Для оценки нестабильности в пораженном позвоночно-двигательном сегменте пользовались шкалой SINS. Всем пациентам выполнено паллиативное хирургическое лечение в объеме окципитоспондилодеза с биопсией новообразования из заднего доступа.</p></sec><sec><title>Результаты</title><p>Результаты. Средний возраст больных составил 60 [44; 66] лет. У всех пациентов до операции отмечался выраженный болевой синдром, средняя интенсивность боли по визуально аналоговой шкале боли составиляла 8 баллов. В предоперационном периоде 6 (85 %) больных по шкале Frankel отнесены к группе Е, 1 (14 %) – к группе С. После операции у 6 (85 %) больных динамика неврологического статуса отсутствовала, однако по шкале Karnofsky отмечалось улучшение до 10 баллов вследствие регресса болевого синдрома до 1 балла по визуально аналоговой шкале боли. У 1 (14 %) больного вследствие мальпозиции ламинарного крючка в послеоперационном периоде развился гемипарез. Cредняя продолжительность выполненных оперативных вмешательств составила 337,5 [315; 345] мин, средняя интраоперационная кровопотеря – 300 [300; 800] мл. У 6 из 7 больных (85 %) динамика неврологического статуса после операции отсутствовала, а по шкале Karnofsky отмечалось улучшение до 10 баллов вследствие регресса болевого синдрома до среднего значения 1 [1; 2] балл по ВАШ.</p></sec><sec><title>Заключение</title><p>Заключение. Полученные результаты свидетельствуют о возможностях клинического применения минимальных по травматичности технологий в хирургическом лечении метастатических опухолей краниовертебральной зоны.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose of the study</title><p>Purpose of the study. Elaboration of a surgical technique to manage patients with metastatic lesions of the craniovertebral region.</p></sec><sec><title>Patients and methods</title><p>Patients and methods. The study included 7 patients with metastatic lesions of the craniovertebral region, who’ve been operated on for severe instability, pain syndrome, neurological deficit in the period from 01/01/2014 to 09/30/2022. To assess the neurological status and patients’ condition the Frankel and Karnofsky scales were used on the day of admission and discharge of the patients from the hospital. Pain intensity was assessed using a visual analog pain scale (VAS). To assess instability in the affected spinal motion segment the SINS scale was used. All patients underwent palliative surgical treatment in the amount of occipitospondylodesis with a biopsy of the neoplasm from the posterior approach.</p></sec><sec><title>Results</title><p>Results. The average age of patients was 60 [44; 66] years. All patients had a marked pain syndrome prior to the surgery. The average pain intensity according to the visual analog pain scale was 8 points. In the preoperative period, 6 (85 %) patients on the Frankel scale were assigned to group E, 1 (14 %) – to group C. In 6 (85 %) patients there was no dynamics in the neurological status following the surgery, however according to the Karnofsky scale there was an improvement up to 10 points due to the regression of the pain syndrome down to 1 point on the visual analog scale. Hemiparesis developed in 1 (14 %) patient due to malposition of the laminar hook in the postoperative period. The average duration of surgical interventions made up 337.5 [315; 345] min, the average intraoperative blood loss made up 300 [300; 800] ml. In 6 out of 7 patients (85 %) there was no neurological status dynamics after the surgery, and according to the Karnofsky scale an improvement up to 10 points was noted due to regression of the pain syndrome to an average value of 1 [1; 2] VAS score.</p></sec><sec><title> Conclusion</title><p> Conclusion. The obtained results indicate the clinical application possibilities of minimally traumatic surgical technologies for the treatment of craniovertebral zone metastatic tumors.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>метастатические опухоли</kwd><kwd>краниовертебральная область</kwd><kwd>хирургическое лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>metastatic tumors</kwd><kwd>craniovertebral area</kwd><kwd>surgical treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кит О. И., Закондырин Д. Е., Росторгуев Э. Е., Юндин С. В. Особенности хирургического лечения синдрома эпидуральной компрессии у пациентов со злокачественными опухолями позвонков. 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