cancerspЮжно-Российский онкологический журнал/ South Russian Journal of CancerSouth Russian Journal of Cancer2686-9039АНО "Перспективы онкологии"10.37748/2686-9039-2026-7-1-7SIEIJAcancersp-380Research ArticleОБЗОРЫREVIEWSПрогностическая значимость исследований CD44 и CK19 при плоскоклеточном раке головы и шеиPrognostic significance of CD44 and CK19 expression in head and neck squamous cell carcinomahttps://orcid.org/0009-0006-2235-1807ЮияоХаньYuyaoHan

 

Хань Юияо – аспирант кафедры, онкологии, радиотерапии и реконструктивной хирургии ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет), г. Москва, Российская Федерация

ORCID: https://orcid.org/0009-0006-2235-1807

 

Yuyao Han – PhD student, Department of Oncology, Radiotherapy and Reconstructive Surgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

ORCID: https://orcid.org/0009-0006-2235-1807

2879320079@qq.comhttps://orcid.org/0000-0003-4598-8625СамойловаС. И.SamoylovaS. I.

 

Самойлова Светлана Ивановна – к.м.н., доцент кафедры, онкологии, радиотерапии и реконструктивной хирургии ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет), г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0003-4598-8625, eLibrary SPIN: 8823-4106, AuthorID: 705453, Scopus Author ID: 57197869441

 

Svetlana I. Samoylova – Cand. Sci. (Medicine), Associate Professor of the Department of Oncology, Radiotherapy and Reconstructive Surgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

ORCID: https://orcid.org/0000-0003-4598-8625, eLibrary SPIN: 8823-4106, AuthorID: 705453, Scopus Author ID: 57197869441

https://orcid.org/0000-0002-0909-6278РешетовИ. В.ReshetovI. V.

 

Решетов Игорь Владимирович – д.м.н., профессор, академик РАН, директор Института кластерной онкологии им. проф. Л.Л. Левшина ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Минздрава России (Сеченовский Университет), г. Москва, Российская Федерация; заведующий кафедрой онкологии, радиотерапии и реконструктивной хирургии Института клинической медицины им. Н.В. Склифосовского ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Минздрава России (Сеченовский Университет), г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0002-0909-6278, eLibrary SPIN: 3845-6604, AuthorID: 103745, Scopus Author ID: 6701353127

 

Igor V. Reshetov – Dr. Sci. (Medicine), Professor, Academician of the Russian Academy of Sciences, Director of the Levshin Institute of Cluster Oncology, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; Head of the Department of Oncology, Radiotherapy and Reconstructive Surgery at the N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

ORCID: https://orcid.org/0000-0002-0909-6278, eLibrary SPIN: 3845-6604, AuthorID: 103745, Scopus Author ID: 6701353127

https://orcid.org/0009-0003-4512-4728ЩицзюньСюйShijunXu

 

Сюй Щицзюнь – аспирант кафедры, онкологии, радиотерапии и реконструктивной хирургии ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Минздрава России (Сеченовский Университет), г. Москва, Российская Федерация

ORCID: https://orcid.org/0009-0003-4512-4728

 

Shijun Xu – PhD student, Department of Oncology, Radiotherapy and Reconstructive Surgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

ORCID: https://orcid.org/0009-0003-4512-4728

https://orcid.org/0009-0007-1231-2289ДавидюкД. Н.DavidyukD. N.

 

Давидюк Дмитрий Николаевич – аспирант Института клинической морфологии и цифровой патологии ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Минздрава России (Сеченовский Университет), г. Москва, Российская Федерация

ORCID: https://orcid.org/0009-0007-1231-2289

 

Dmitriy N. Davidyuk – PhD student, Institute of Clinical Morphology and Digital Pathology, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

ORCID: https://orcid.org/0009-0007-1231-2289

https://orcid.org/0009-0009-2320-0834CиньиЯнXinyiYang

 

Ян Синьи – аспирант кафедры, онкологии, радиотерапии и реконструктивной хирургии ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Минздрава России (Сеченовский Университет), г. Москва, Российская Федерация

ORCID: https://orcid.org/0009-0009-2320-0834

 

Xinyi Yang – PhD student, Department of Oncology, Radiotherapy and Reconstructive Surgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

ORCID: https://orcid.org/0009-0009-2320-0834

https://orcid.org/0009-0002-3962-5924НводоП. Т.NwodoP. T.

 

Нводо Прешес Точукву – аспирант кафедры, онкологии, радиотерапии и реконструктивной хирургии ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Минздрава России (Сеченовский Университет), г. Москва, Российская Федерация

ORCID: https://orcid.org/0009-0002-3962-5924

 

Precious Nwodo – PhD student, Department of Oncology, Radiotherapy and Reconstructive Surgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

ORCID: https://orcid.org/0009-0002-3962-5924

https://orcid.org/0000-0002-7704-1658СукорцеваН. С.SukortsevaN. S.

 

Сукорцева Наталья Сергеевна – ассистент кафедры, онкологии, радиотерапии и реконструктивной хирургии ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет), г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0002-7704-1658, eLibrary SPIN: 1728-6019, AuthorID: 934190, 57204624050, WoS ResearcherID: ABD-9539-2021

 

Natalya S. Sukortseva – assistant at the Department of Oncology, Radiotherapy and Reconstructive Surgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

ORCID: https://orcid.org/0000-0002-7704-1658, eLibrary SPIN: 1728-6019, AuthorID: 934190, 57204624050, WoS ResearcherID: ABD-9539-2021

https://orcid.org/0000-0002-6946-6146ДемураТ. А.DemuraT. A.

 

Демура Татьяна Александровна – д.м.н., профессор директор Института клинической морфологии и цифровой патологии ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет), г. Москва, Российская Федерация

ORICD: https://orcid.org/0000-0002-6946-6146, eLibrary SPIN: 2198-5765, AuthorID: 592270, Scopus Author ID: 25936132400

 

 

Tatiana A. Demura – Dr. Sci. (Medicine), Professor, Director, of the Institute of Clinical Morphology and Digital Pathology, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

ORICD: https://orcid.org/0000-0002-6946-6146, eLibrary SPIN: 2198-5765, AuthorID: 592270, Scopus Author ID: 25936132400

Первый Московский государственный медицинский университет им. И. М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет) <p> г. Москва, Российская ФедерацияSechenov First Moscow State Medical University (Sechenov University) <p> Moscow, Russian Federation2026130320267195110Copyright &#x00A9; Юияо Х., Самойлова С.И., Решетов И.В., Щицзюнь С., Давидюк Д.Н., Cиньи Я., Нводо П.Т., Сукорцева Н.С., Демура Т.А., 20262026Юияо Х., Самойлова С.И., Решетов И.В., Щицзюнь С., Давидюк Д.Н., Cиньи Я., Нводо П.Т., Сукорцева Н.С., Демура Т.А.Yuyao H., Samoylova S.I., Reshetov I.V., Shijun X., Davidyuk D.N., Xinyi Y., Nwodo P.T., Sukortseva N.S., Demura T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.cancersp.com/jour/article/view/380Цель исследования

Цель исследования. Анализ и обобщение современных научных сведений о роли экспрессии CD44 и CK19 в патогенезе плоскоклеточного рака головы и шеи (ПРГШ), их диагностической и прогностической значимости, а также возможностей клинического применения и перспективах.

Материалы и методы

Материалы и методы. Обзор основан на анализе публикаций в базах данных PubMed, Scopus, Web of Science и Embase, используя ключевые слова: «head and neck squamous cell carcinoma», «CD44», «CK19», «biomarker», «prognosis». Критерии включения: оригинальные исследования и метаанализы; исключались дублирующиеся и нерелевантные публикации. Сравнивались методы выявления CD44 и CK19, а также клинические и демографические характеристики изученных когорт в различных работах.

Результаты

Результаты. Повышенная или аномальная экспрессия CD44 связана с большей агрессивностью, риском рецидива и метастазирования ПРГШ, а отдельные изоформы (CD44v4, CD44v6) могут указывать на резистентность и неблагоприятное течение. На экспрессию CD44 влияет ряд факторов (локализация, возраст, пол). Высокие уровни CK19 ассоциированы с низкой дифференцировкой, высокой злокачественностью и рисками рецидива; этот маркер часто выявляется при ВПЧ-ассоциированных опухолях. Иммуногистохимические и молекулярные тесты определения CK19 характеризуются высокой чувствительностью и специфичностью. Современные исследования подтверждают тот факт, что совместная оценка CD44 и CK19 повышает точность стратификации риска и клинического мониторинга ПРГШ.

Заключение

Заключение. CD44 и CK19 – перспективные биомаркеры для персонализированного подхода к диагностике и ведению пациентов с ПРГШ. Их комбинация улучшает раннюю стратификацию риска прогрессирования и рецидива, а также выбор оптимальных лечебных методов. Необходимы дальнейшие масштабные исследования и унификация методик для внедрения этих маркеров в клиническую практику с целью повышения выживаемости пациентов и улучшения их качества жизни.

Purpose of the study

Purpose of the study. To analyze and synthesize current scientific evidence on the role of CD44 and CK19 expression in the pathogenesis of head and neck squamous cell carcinoma (HNSCC), their diagnostic and prognostic significance, as well as their potential clinical applications and future perspectives.

Materials and methods

Materials and methods. The review was based on an analysis of publications from PubMed, Scopus, Web of Science, and Embase using the following keywords: “head and neck squamous cell carcinoma”, “CD44”, “CK19”, “biomarker”, and “prognosis”. The inclusion criteria comprised original studies and meta-analyses; duplicate and irrelevant publications were excluded. Methods for detecting CD44 and CK19, as well as the clinical and demographic characteristics of the studied cohorts, were compared across the included studies.

Results

Results. Increased or aberrant CD44 expression was associated with greater tumor aggressiveness, a higher risk of recurrence and metastasis in HNSCC, while specific isoforms (CD44v4, CD44v6) may indicate therapeutic resistance and an unfavorable disease course. CD44 expression was influenced by several factors, including tumor site, age, and sex. Elevated CK19 levels were associated with poor differentiation, higher malignancy, and an increased risk of recurrence; this marker was frequently detected in HPV-associated tumors. Immunohistochemical and molecular assays for CK19 demonstrated high sensitivity and specificity. Recent studies confirm that the combined assessment of CD44 and CK19 improves the accuracy of risk stratification and clinical monitoring in HNSCC.

Conclusion

Conclusion. CD44 and CK19 are promising biomarkers for a personalized approach to the diagnosis and management of patients with HNSCC. Their combined use improves early risk stratification for disease progression and recurrence, as well as the selection of optimal treatment strategies. Further large-­scale studies and methodological standardization are required to implement these biomarkers in clinical practice to improve patient survival and quality of life.

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The authors declare that there are no conflicts of interest present.