Clinical use of xenon-oxygen therapy to restore neuropsychological and adaptive status in young women with hormone-dependent breast cancer after total ovarian suppression

Purpose of the study. The objective of this study is to evaluate the clinical effectiveness of activation xenon-oxygen therapy (XOT) in correcting neuropsychological and adaptive status in patients diagnosed with hormone-dependent breast cancer who have undergone total ovariectomy.

Patients and methods. We analyzed data on the intensity of clinical symptoms, the dynamics and intensity of adaptive responses (AR) with calculation of the anti-stress/stress ratio, as well as the bioelectric brain activity of 36 young patients diagnosed with hormone-dependent breast cancer, presenting with clinical signs of post-mastectomy syndrome (PMES) and early signs of post-ovariectomy syndrome (POES).

Results. In determining the distribution of stress and anti-stress reactions, a postoperative phase transition from a physiological to a pathological state was reliably established. In the postoperative period following ovariectomy, normal reaction types were observed in 11.3 % of cases. The predominant response was the stress reaction. Analysis of AR structure in patients with PMES and POES manifestations demonstrated a clear advantage for XOT. During rehabilitation, patients in the non-XOT group did not achieve full restoration of AR structure to baseline values, with the stress response persisting in 58.7 % of cases. In contrast, the XOT group demonstrated anti-stress reactions, with no stress reactions detected. Furthermore, analysis of the bioelectric activity of the brain in patients after two hormone-reducing surgeries revealed significant alterations in the spectral power of the electroencephalogram (EEG). These changes were indicative of a balanced state of excitation and inhibition, suggesting an equilibrium in neural processes underlying cognitive function.

Conclusion. Xenon, as a biologically active factor, functions as a catalyst for complex functional transformations within the body's regulatory systems. Xenon-based therapy induces a substantial reduction in stress reactions, highlighting the pronounced biotropic effect of xenon in restoring the adaptive status of the female body.

1. Malignant tumors: Practical recommendations of RUSSCO #3s2. Ed. by Tyulandin SA, Artamonova EV, Zhigulev AN, Zhukova LG, Koroleva IA, Parokonnaya AA, Semiglazova TYu, Stenina MB, Frolova MA. 2023; 13(3S2): 157–200. (In Russ.) https://doi.org/10.18027/2224-5057-2023-13-3s2-1-157-200.

2. Pestereva EV, Chulkova VA, Semiglazova TY, Ulrich EG, Pestereva OA. Assessment of the psychological status of patients with gynecological cancer in the process of psychological rehabilitation. The Scientific Notes of the Pavlov University. 2018; 25(1): 62-67. (In Russ.) https://doi.org/10.24884/1607-4181-2018-25-1-62-67.

3. Kulavskii VA, Kulavskii EV, Ziganshin AM. Surgical menopause in women of reproductive age. Obstetrics, Gynecology and Reproduction. 2016; 10(4): 105-113. (In Russ.) https://doi.org/10.17749/2313-7347.2016.10.4.105-1133

4. Yureneva SV, Ermakova EI. Menopause and menopause in a woman. Obstetrics and Gynecology. 2018; 7: 32-8. (In Russ.) https://dx.doi.org/10.18565/aig.2018.7.32-38

5. Ushakov IB, Pyatibrat AO. Prospects of Xenon Application in Functional Recovery and Rehabilitation of Patients Working in Extreme Occupational Environments. Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2022; (4): 40-54. (In Russ.) https://doi.org/10.25016/2541-7487-2022-0-4-40-54.

6. Rozenko LYa, Zinkovich MS, Arapova YuYu, Protasova TP, Shikhlyarova AI, Popova NN, Korobeynikova EP, Vashchenko LN, Ushakova ND. Effect of xenon on spatial organization of bioelectric activity of the brain. Izvestiya Vuzov. Severo-Kavkazskii region. Natural science. 2017;4-2 (111-118). (In Russ.) https://doi.org/10.23683/0321-3005-2017-4-2-111-118.

7. Kit OI, Francijanc E., Men'shenina AP, Moiseenko TI, Ushakova ND, Popova NN, Jakushin AV. Rol' plazmafereza i ksenonterapii v korrekcii ostryh pos ledstvij hirurgicheskoj menopauzy u bol'nyh rakom shejki matki. Politematicheskij setevoj jelektronnyj nauchnyj zhur nal Kubanskogo gosudarstvennogo agrarnogo universiteta. Krasnodar, KubGAU, 2016; 03(117). IDA [article ID]: 1171603029. http://ej.kubagro.ru/2016/03/pdf/29.pdf.

8. Vikhlyaeva EM. Postmenopausal therapy. Effects on menopause-related symptoms, the course of chronic diseases, and quality of life. Moscow: MED-pressinform, 2008. 448 p.

9. Malignant tumors: Practical recommendations of RUSSCO #3s2. Ed. by Ionova TI, Nikitinoi TP, Snegovoi AV. 2017; 7(3S2): 586– 591.

10. Shikhlyarova AI, Zhukova GV, Mashchenko NM. Some recommendation and examples in the activation therapy practical implementation (according to L. K. Garkavi, E. B. Kvakina and M. A. Ukolova's research studies). Cardiometry. 2015; 7:57.

11. Rodriguez-Larios J, Alaerts K. Tracking Transient Changes in the Neural Frequency Architecture: Harmonic Relationships between Theta and Alpha Peaks Facilitate Cognitive Performance. J Neurosci. 2019; 39(32):6291-6298. https://doi.org/10.1523/JNEUROSCI.2919-18.2019

12. Rozenko DA, Shikhlyarova AI, Vashchenko LN, Popova NN, Arapova YuYu, Ardzha AYu, Korobov AA. Neuropsychological features of patients of reproductive age diagnosed with breast cancer at the stage of surgical treatment using xenon-oxygen therapy. Research and Practical Medicine Journal (Issled. prakt. med.). 2021; 8(3): 10-20. (In Russ.) https://doi.org/10.17709/2410-1893-2021-8-3-1