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Blood levels of growth and progression factors in patients with locally advanced breast cancer during neoadjuvant chemotherapy

https://doi.org/10.37748/2686-9039-2021-2-3-1

Abstract

Purpose of the study. An analysis of blood levels of TGF-β, TGFR2, TNF-α, TNF-αR1, TNF-αR2, CD44 and MMP9 in patients with various biological subtypes of breast cancer receiving neoadjuvant chemotherapy.
Materials and methods. This article presents an analysis of levels of growth and progression factors (TGF-β, TGFR2, TNF-α, TNF-αR1, TNF-αR2, CD44 and MMP9) in the blood of 162 patients with various biological subtypes of locally advanced breast cancer receiving 8 cycles of neoadjuvant chemotherapy.
Results. Levels of TGF-β, TGFR2, TNF, TNF-α, TNFR1, TNFR2, CD44, MMP9 in patients with all BC subtypes were high before the treatment. After chemotherapy cycles, the values decreased statistically significantly in all BC subtypes: CD44 decreased by 25.2 %, 30 % and 54.7 % in luminal A, luminal B and TNBC, respectively; TNFα– by 26.2 %, 48.3 % and 50.8 %, respectively; TNFα-R1 – by 52.1 %, 39.2 % and 50.3 % respectively; TNFα-R2 – by 31.7 %, 32.8 % and 41.9 % respectively; MMP9 – 35.3 %, 32.6 % and 43.3 % respectively.
Conclusions. We identified a combination of growth and progression factors which determines the chemotherapy sensitivity and resistance in all subtypes of breast cancer; so, a decline in the levels of TGF-β, TNFα, MMP9 and CD44 after neoadjuvant chemotherapy predicts further remission for at least 3 years. On the contrary, stabilization or an increase of these indicators leads to the early tumor progression.

About the Authors

E. M. Frantsiyants
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Elena M. Franzyants – Dr. Sci. (Biol.), professor, deputy general director for science

SPIN: 9427-9928

AuthorID: 462868

ResearcherID: Y-1491-2018

Scopus Author ID: 55890047700 

63 14 line str., Rostov-on-Don 344037



N. Yu. Samaneva
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Natalia Yu. Samaneva – Cand. Sci. (Med.), junior researcher of the department of drug treatment of tumors, doctor of the Department of antitumor Drug Therapy No. 2

SPIN: 1181-0659

AuthorID: 734488

ResearcherID: AAH-7905-2019

Scopus Author ID: 57192874030 

63 14 line str., Rostov-on-Don 344037



L. Yu. Vladimirova
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Lubov Yu. Vladimirova – Dr. Sci. (Med.), professor, head of the department of antitumor Drug Therapy No. 1, Head of Tumor drug Therapy Department

SPIN: 4857-6202

AuthorID: 289090

ResearcherID: U-8132-2019

Scopus Author ID: 7004401163 

63 14 line str., Rostov-on-Don 344037



A. E. Storozhakova
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Anna E. Storozhakova – Cand. Sci. (Med.), head of the department of antitumor Drug Therapy No. 2

SPIN: 2804-7474

AuthorID: 734057

ResearcherID: U-6202-2019

Scopus Author ID: 57045921800 

63 14 line str., Rostov-on-Don 344037



E. A. Kalabanova
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Elena A. Kalabanova – Cand. Sci. (Med.), senior researcher of tumor drug therapy department, doctor of the department of antitumor Drug Therapy No. 2

SPIN: 9090-3007

AuthorID: 734992

ResearcherID: V-2943-2019

Scopus Author ID: 57046062200 

63 14 line str., Rostov-on-Don 344037



S. N. Kabanov
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Sergey N. Kabanov – Cand. Sci. (Med.), doctor of the department of antitumor Drug Therapy No. 2

SPIN: 6369-0824

AuthorID: 794858

ResearcherID: V-3023-2019

Scopus Author ID: 57045732600 

63 14 line str., Rostov-on-Don 344037



A. V. Tishina
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Anna V. Tishina – doctor of the department of antitumor Drug Therapy No. 2

SPIN: 7686-3707

AuthorID: 965165

ResearcherID: H-2460-2018 

63 14 line str., Rostov-on-Don 344037



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For citations:


Frantsiyants E.M., Samaneva N.Yu., Vladimirova L.Yu., Storozhakova A.E., Kalabanova E.A., Kabanov S.N., Tishina A.V. Blood levels of growth and progression factors in patients with locally advanced breast cancer during neoadjuvant chemotherapy. South Russian Journal of Cancer. 2021;2(3):6-12. https://doi.org/10.37748/2686-9039-2021-2-3-1

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ISSN 2686-9039 (Online)