Blood levels of growth and progression factors in patients with locally advanced breast cancer during neoadjuvant chemotherapy
https://doi.org/10.37748/2686-9039-2021-2-3-1
Abstract
Purpose of the study. An analysis of blood levels of TGF-β, TGFR2, TNF-α, TNF-αR1, TNF-αR2, CD44 and MMP9 in patients with various biological subtypes of breast cancer receiving neoadjuvant chemotherapy.
Materials and methods. This article presents an analysis of levels of growth and progression factors (TGF-β, TGFR2, TNF-α, TNF-αR1, TNF-αR2, CD44 and MMP9) in the blood of 162 patients with various biological subtypes of locally advanced breast cancer receiving 8 cycles of neoadjuvant chemotherapy.
Results. Levels of TGF-β, TGFR2, TNF, TNF-α, TNFR1, TNFR2, CD44, MMP9 in patients with all BC subtypes were high before the treatment. After chemotherapy cycles, the values decreased statistically significantly in all BC subtypes: CD44 decreased by 25.2 %, 30 % and 54.7 % in luminal A, luminal B and TNBC, respectively; TNFα– by 26.2 %, 48.3 % and 50.8 %, respectively; TNFα-R1 – by 52.1 %, 39.2 % and 50.3 % respectively; TNFα-R2 – by 31.7 %, 32.8 % and 41.9 % respectively; MMP9 – 35.3 %, 32.6 % and 43.3 % respectively.
Conclusions. We identified a combination of growth and progression factors which determines the chemotherapy sensitivity and resistance in all subtypes of breast cancer; so, a decline in the levels of TGF-β, TNFα, MMP9 and CD44 after neoadjuvant chemotherapy predicts further remission for at least 3 years. On the contrary, stabilization or an increase of these indicators leads to the early tumor progression.
About the Authors
E. M. FrantsiyantsRussian Federation
Elena M. Franzyants – Dr. Sci. (Biol.), professor, deputy general director for science
SPIN: 9427-9928
AuthorID: 462868
ResearcherID: Y-1491-2018
Scopus Author ID: 55890047700
63 14 line str., Rostov-on-Don 344037
N. Yu. Samaneva
Russian Federation
Natalia Yu. Samaneva – Cand. Sci. (Med.), junior researcher of the department of drug treatment of tumors, doctor of the Department of antitumor Drug Therapy No. 2
SPIN: 1181-0659
AuthorID: 734488
ResearcherID: AAH-7905-2019
Scopus Author ID: 57192874030
63 14 line str., Rostov-on-Don 344037
L. Yu. Vladimirova
Russian Federation
Lubov Yu. Vladimirova – Dr. Sci. (Med.), professor, head of the department of antitumor Drug Therapy No. 1, Head of Tumor drug Therapy Department
SPIN: 4857-6202
AuthorID: 289090
ResearcherID: U-8132-2019
Scopus Author ID: 7004401163
63 14 line str., Rostov-on-Don 344037
A. E. Storozhakova
Russian Federation
Anna E. Storozhakova – Cand. Sci. (Med.), head of the department of antitumor Drug Therapy No. 2
SPIN: 2804-7474
AuthorID: 734057
ResearcherID: U-6202-2019
Scopus Author ID: 57045921800
63 14 line str., Rostov-on-Don 344037
E. A. Kalabanova
Russian Federation
Elena A. Kalabanova – Cand. Sci. (Med.), senior researcher of tumor drug therapy department, doctor of the department of antitumor Drug Therapy No. 2
SPIN: 9090-3007
AuthorID: 734992
ResearcherID: V-2943-2019
Scopus Author ID: 57046062200
63 14 line str., Rostov-on-Don 344037
S. N. Kabanov
Russian Federation
Sergey N. Kabanov – Cand. Sci. (Med.), doctor of the department of antitumor Drug Therapy No. 2
SPIN: 6369-0824
AuthorID: 794858
ResearcherID: V-3023-2019
Scopus Author ID: 57045732600
63 14 line str., Rostov-on-Don 344037
A. V. Tishina
Russian Federation
Anna V. Tishina – doctor of the department of antitumor Drug Therapy No. 2
SPIN: 7686-3707
AuthorID: 965165
ResearcherID: H-2460-2018
63 14 line str., Rostov-on-Don 344037
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Supplementary files
Review
For citations:
Frantsiyants E.M., Samaneva N.Yu., Vladimirova L.Yu., Storozhakova A.E., Kalabanova E.A., Kabanov S.N., Tishina A.V. Blood levels of growth and progression factors in patients with locally advanced breast cancer during neoadjuvant chemotherapy. South Russian Journal of Cancer. 2021;2(3):6-12. https://doi.org/10.37748/2686-9039-2021-2-3-1