ABOUT EXPANDING OPTIONS FOR USING BALB/C NUDE MICE FOR EXPERIMENTAL STUDY OF HUMAN MALIGNANT TUMORS IN VIVO
https://doi.org/10.37748/2687-0533-2020-1-2-4
Abstract
The article has a problematic scripting nature. At the present stage, in addition to objective factors that make it difficult to create adequate experimental models of human oncogenesis, there is a significant backlog of domestic science in the development of this direction. This reduces the availability for Russian specialists of humanized immunodeficient animals corresponding to the level of research tasks. Based on the analysis of literature data, we discuss approaches that can expand the use of a widely available immunodeficiency animal model‑BALB/c nude mice. The possibility of using human mesenchymal stem cells that are not rejected by BALB/C Nude mice for local humanization of immunodeficient animals and improving the structural and functional characteristics of xenografts is considered. The possibility of obtaining xenografts of human glioblasts supported in the body of immunocompetent BALB/c mice after serial passages of organotypic tumor spheroids in the brain of BALB/c nude mice is analyzed.
About the Authors
G. V. Zhukova
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. Sci. (Biol.), Senior Researcher at the Testing Laboratory Center
SPIN: 1887–7415, AuthorID: 564827,
Scopus Author ID: 7005456284, Researcher ID: Y-4243–2016
63 14 line str., Rostov-on-Don 344037, Russian Federation
A. I. Shikhliarova
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation
Russian Federation
Dr. Sci. (Biol.), Professor, Senior Researcher at the Testing Laboratory Center
SPIN: 6271–0717, AuthorID: 482103, Scopus Author ID: 6507723229
63 14 line str., Rostov-on-Don 344037, Russian Federation
A. B. Sagakyants
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. Sci. (Biol.), Associate Professor, Head of the Tumor Immunophenotyping Laboratory
SPIN: 7272–1408, AuthorID: 426904,
Scopus Author ID: 24329773900, Researcher ID: M-8378–2019
63 14 line str., Rostov-on-Don 344037, Russian Federation
T. P. Protasova
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. Sci. (Biol.), Researcher at the Testing Laboratory Center
SPIN: 4542–3581, Author ID: 760427
63 14 line str., Rostov-on-Don 344037, Russian Federation
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Review
For citations:
Zhukova G.V., Shikhliarova A.I., Sagakyants A.B., Protasova T.P. ABOUT EXPANDING OPTIONS FOR USING BALB/C NUDE MICE FOR EXPERIMENTAL STUDY OF HUMAN MALIGNANT TUMORS IN VIVO. South Russian Journal of Cancer. 2020;1(2):28-35. https://doi.org/10.37748/2687-0533-2020-1-2-4
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