UNITED IMMUNOLOGICAL FORUM: CURRENT TRENDS IN THE DEVELOPMENT OF FUNDAMENTAL AND APPLIED ONCOIMMUNOLOGY (NOVOSIBIRSK, 2019)
https://doi.org/10.37748/2687-0533-2020-1-2-5
Abstract
The work provides information on the results of the Joint Immunological Forum, which was held from June 24 to 29, 2019 in Novosibirsk. The modern directions of the development of fundamental and applied immunology are analyzed. Particular attention is paid to the discussion of the most issues identified in the section "Immunopathogenetic bases of tumor growth", which also presented the results of studies conducted at the National Medical Research Centre for Oncology of the Ministry of Health of Russia for the study of isolation and study of the biological properties of tumor stem cells. Noteworthy are the new advances in modern immunology, which clarify the hierarchical structure of lymphocyte populations, with the separation of various minor subpopulations based on the phenotypic, molecular genetic and functional properties of cells, whose role in ensuring the integrity of the body has not been fully studied. In addition to theoretical reports, during this Forum the results of using new methodological approaches to study the structural and functional organization of individual links of innate and adaptive immunity both under model conditions and during the development of various human diseases were presented, the most promising ways to improve analytical and technological platforms were identified. In the crayfish of the Forum, several advanced training programs were implemented for employees of various levels of practical health care and fundamental science.
About the Author
A. B. Sagakyants
National Medical Research Centre for
Oncology of the Ministry of Health of Russia
Russian Federation
Russian Federation
Cand. Sci. (Biol.), associate professor, head of the laboratory of tumor immunophenotyping
SPIN: 7272-1408, AuthorID: 426904, Scopus Author ID: 24329773900,
Researcher ID: M-8378-2019
63 14 line str., Rostov-on-Don 344037, Russian Federation
References
1. Protsenko SA, Antimonik NYu, Bershtein LM, Novik AV, Nosov DA, Petenko NN, et al. Practical guidelines for managing immune‑mediated adverse events. Malignant tumors: Practical guidelines for RUSSCO #3s2. 2018; 8 (3s2): 636–665. https://doi.org/10.18027/2224–5057–2018–8‑3s2–636–665
2. Savchenko AA, Borisov AG, Kudryavtsev IV, Gvozdev II, Moshev AV. Phenotypic peculiarities of dendritiс cells differentiated from blood monocytes in patients with kidney cancer. Medical Immunology. 2018; 20(2): 215–226. (In Russian). https://doi.org/10.15789/1563–0625–2018–2‑215–226
3. Vlahakis A, Debnath J. The Interconnections between Autophagy and Integrin‑Mediated Cell Adhesion. J Mol Biol. 2017 Feb 17; 429 (4): 515–530. https://doi.org/10.1016/j.jmb.2016.11.027
4. Ricci‑Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C, et al. Identification and expansion of human colon‑cancer‑initiating cells. Nature. 2007 Jan 4; 445 (7123): 111–115. https://doi.org/10.1038/nature05384
5. Qureshi‑Baig K, Ullmann P, Rodriguez F, Frasquilho S, Nazarov PV, Haan S, et al. What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue. PLoS ONE. 2016 Jan 8; 11 (1): e0146052. https://doi.org/10.1371/journal.pone.0146052
6. Sagakyants AB, Novikova IA, Ulyanova EP, Zolotareva EI, Shaposhnikov AV, Dzhenkova EA. Tumor stem cells and their micro‑environment: the role in the development of the tumor. Russian journal of immunology. 2019; 13 (22) (2): 512–514. (In Russian).
7. Hanahan D, Weinberg RA. The Hallmarks of Cancer. Cell. 2000 Jan 7;100 (1): 57–70. https://doi.org/10.1016/s0092–8674 (00)81683–9
8. Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011 Mar25; 331 (6024): 1565–1570. https://doi.org/10.1126/science.1203486
9. Mantovanni A, Allavena P, Sica A, Balkwill F. Cancer‑related inflammation. Nature. 2008 Jul 24; 454 (7203): 436–444. https://doi.org/10.1038/nature07205
10. Fang D, Zhu J. Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets. J. Exp. Med. 2017 Jul 3; 214 (7): 1861–1876. https://doi.org/10.1084/jem.20170494
11. Rupaimoole R, Calin GA, Lopez‑Berestein G, Sood AK. MicroRNA deregulation in cancer cells and the tumor microenvironment. Cancer Discov. 2016 Mar; 6(3): 235–246. https://doi.org/10.1158/2159–8290.CD‑15–0893
12. Teng MWL, Ngiow SF, Ribas A, Smyth MJ. Classifying Cancers Based on T‑cell Infiltration and PD‑L1. Cancer Res. 2015 Jun; 75 (11): 2139–2145. https://doi.org/10.1158/0008–5472.CAN‑15–0255
13. Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014 Mar 27; 157 (1): 121–141. https://doi.org/10.1016/j.cell.2014.03.011
14. Villéger R, Lopès A, Veziant J, Gagnière J, Barnich N, Billard E, et al. Microbial markers in colorectal cancer detection and or prognosis World J. Gastroenterol. 2018 Jun 14; 24 (22): 2327–2347. https://doi.org/10.3748/wjg.v24.i22.2327
15. Greenplate AR, Johnson DB, Ferrell JrPB, Irish JM. Systems immune monitoring in cancer therapy. Eur J Cancer. 2016 Jul 1; 61: 77–84. https://doi.org/10.1016/j.ejca.2016.03.085
16. Spitzer MH, Nolan GP. Mass Cytometry: Single Cells, Many Features. Cell. 2016 May 5; 165 (4): 780–791. https://doi.org/10.1016/j.cell.2016.04.019
17. Chattopadhyay PK, Roederer M. A mine is a terrible thing to waste: high content, single cell technologies for comprehensive immune analysis. American Journal of Transplantation 2015; 15: 1155–1161. https://doi.org/10.1111/ajt.13193
18. Li N, V van Unen, Abdelaa T, Guo N, Kasatskaya SA, Ladell K, et al. Memory CD4+ T cells are generated in the human fetal intestine. Nat Immunol. 2019; 20 (3): 301–312. https://doi.org/10.1038/s41590–018–0294–9
19. Chen Z, Huang A, Sun J, Jiang T, Qin F, Wu A. Inference of immune cell composition on the expression profiles of mouse tissue. Sci Rep. 2017 Jan 13; 7: 40508. https://doi.org/10.1038/srep40508
Review
For citations:
Sagakyants A.B. UNITED IMMUNOLOGICAL FORUM: CURRENT TRENDS IN THE DEVELOPMENT OF FUNDAMENTAL AND APPLIED ONCOIMMUNOLOGY (NOVOSIBIRSK, 2019). South Russian Journal of Cancer. 2020;1(2):36-45. https://doi.org/10.37748/2687-0533-2020-1-2-5
Views:
14347
Email this article 